Figure 1 | Scientific Reports

Figure 1

From: CANCERSIGN: a user-friendly and robust tool for identification and classification of mutational signatures and patterns in cancer genomes

Figure 1

Tool functionality map. This diagram abstracts the functional features of CANCERSIGN. The user can either choose to extract mutational signatures or cluster the tumor samples. Signatures can either be deciphered in the conventional format which are the spectrums over 96 mutation types (3-mer motifs) or in 5-mer format. For extracting 5-mer signatures, the mutational motifs (penta-nucleotides) are determined based on the set of user defined 3-mer motifs and their flanking bases. In the clustering part, the user can choose different sets of features to cluster the samples. These feature sets are based on either counts of mutational motifs or based on the contribution of mutational signatures.

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