Figure 6
From: Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury
Localization of FRMD6 in the sciatic nerve, normally (A–C) and 10 hours after nerve ligation (D,E). (A) FRMD6-immunoreactivity is seen in PGP9.5+ axons (arrowheads). (B) FRMD6-immunoreactivity is observed in some CGRP+ axons (arrowheads). (C) FRMD6 co-localizes with the Schwann cell marker GFAP (arrows). (D) Ligation causes a strong accumulation of FRMD6-immunoreactivity on the proximal side of the nerve, in parallel with CGRP-immunoreactivity; merged micrograph shows overlap and co-existence. (E) At high magnification FRMD6-immunoreactivity has a high degree of co-existence with GAP43-immunoreactivity proximal to the ligation (arrowheads). Scale bars indicate 50 μm (B), 100 μm (A,C), 200 μm (D,E).
