Figure 5 | Scientific Reports

Figure 5

From: Human cytomegalovirus promoting endothelial cell proliferation by targeting regulator of G-protein signaling 5 hypermethylation and downregulation

Figure 5

HCMV infected promotes endothelial cell proliferation through low expression of RGS5. (A) Green fluorescence was observed in both the RGS5-transfected and GFP-positive control groups, while that was not observed in the untransfected group. (B) RGS5 expression levels in HUVECs were detected by real-time PCR. RGS5 expression signifcantly increased after RGS5o/e adenovirus infected. (C) RGS5o/e reversible cell proliferation induced by HCMV infected by CCK-8 analysis. (D,E) RGS5o/e reduces the increase in PCNA induced by HCMV infected. RGS5o/e(RGS5-overexpression vector). *P < 0.05 vs control; #P < 0.05 HCMV + HG + ox-LDL vs HCMV or HG + ox-LDL. ΔP < 0.05 HCMV vs HCMV + RGS5 was considered statistically signifcant. Student’s t-test.

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