Figure 2
From: Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the “Liquid Autopsy”
Pathologic features of the prostatic cancer case. (a) Prostate core needle biopsy. Histologically, adenocarcinoma with solid and glandular structures was observed. The tumor cells were negative for ERG based on immunohistochemistry analyses (inset). (b) Prostate at autopsy. Macroscopically, the prostate was of normal size (inset). Histologically, scattered foci of cancer with degenerative changes were present. (c) Liver at autopsy. The liver was extremely enlarged with numerous cancer metastases. (d) Histology of the liver metastasis. The metastatic lesion was predominantly composed of poorly differentiated carcinoma growing in solid nests. (e) Vertebrae at autopsy. Whitish and sclerotic changes were observed in almost all vertebrae, suggestive of osteogenic metastases. (f) Histology of the vertebral metastasis. Thick trabeculae were formed, and the intratrabecular spaces were filled with cancer cells. (g,h) Histology of the lymph node metastases. Poorly differentiated carcinoma composed of atypical cells with enlarged nuclei growing in sheets was observed.
