Figure 3
From: Post-mortem Plasma Cell-Free DNA Sequencing: Proof-of-Concept Study for the “Liquid Autopsy”
Evaluation of somatic mutations detected in cell-free DNA (cfDNA) by whole-exome sequencing. (a) Composition of mutations detected in plasma cfDNA. The classification of mutations was based on whole-exome sequences from eight frozen metastatic tumor tissues (Table 1). This figure is drawn using Excel for Mac (16.16.18) and PowerPoint for Mac (16.16.18), Microsoft Cooperation, Redmond, WA, USA. (b,c) Variant allele frequencies (VAFs) of mutations detected in cfDNA. Box plots indicate the VAF values of mutations classified by category. Each box shows the median (central line), inter-quartile range (IQR; box), and ±1.5 × IQR (whiskers). Mutations classified as “unique to one” (b) were subdivided by tumor sample and are shown in panel (c).
