Table 1 IC50 (cell viability) values of compounds affecting the ubiquitin proteasome machinery in imatinib (IM)-sensitive and IM-resistant GIST cells.

From: Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells

 

IC50 (nM)

CFZ

IXA

DLZ

BO

GIST882

184

82

23

13

GIST-T1

1,679

175

36

26

GIST48

67

41

9

7

GIST430

185

56

12

13

  1. CFZ, carfilzomib; IXA, ixazomib; DLZ, delanzomib; BO, bortezomib. GIST882, GIST-T1 (IM-sensitive); GIST48, GIST430 (IM-resistant).
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