Table 2 EC50 values of 20S inhibition of compounds affecting the ubiquitin proteasome machinery in imatinib (IM)-sensitive and IM-resistant GIST cells.

From: Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells

 

EC50 (nM)

CFZ

IXA

DLZ

BO

GIST882

96

84

13

8

GIST-T1

41

50

5

9

GIST48

52

25

7

6

GIST430

83

42

5

4

  1. CFZ, carfilzomib; IXA, ixazomib; DLZ, delanzomib; BO, bortezomib. GIST882, GIST-T1 (IM-sensitive); GIST48, GIST430 (IM-resistant).
Back to article page