Figure 2
From: Immunomodulatory role of Interleukin-33 in large vessel vasculitis
IL-33 and its receptor ST2 were overexpressed in LVV. (A) Immunofluorescence analyses of aorta tissue specimens from LVV patients revealed that IL-33 was mainly expressed within adventitial vessels and co-localized with endothelial cells with positive von willebrand factor (WF) staining. Immunofluorescence analysis of non-inflammatory aorta did not reveal IL-33 positive staining. (B) Expression of ST2 was mainly observed within the inflammatory infiltrates in aorta tissue specimen. Immunofluorescence analyses of one non-inflammatory aorta show vessels (WF positive staining) without positive IL-33 staining and absence of ST2 staining. Immunofluorescence analysis of non-inflammatory aorta did not reveal ST2 positive staining. (C) The proportion of vessels with positive IL-33 staining was higher in aorta from LVV patients (n = 5) as compared to non-inflammatory controls (n = 3), *P < 0.05. These data are shown as the mean ± SEM.
