Figure 2 | Scientific Reports

Figure 2

From: Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma

Figure 2

P-gp and Bcrp together restrict the brain distribution of ispinesib. The plasma concentrations (A), brain concentrations (B), and brain-to-plasma concentration ratios (C) at 2 and 6 hours following administration of a single intraperitoneal dose of 10 mg/kg ispinesib to FVB wild-type, Bcrp1−/−, Mdr1a/b−/− and Mdr1a/b−/− Bcrp1−/− mice are depicted. **p < 0.01, ***p < 0.001 and ****p < 0.0001 when compared to the wild-type (WT) groups, for statistical testing by one-way ANOVA. Data represent mean ± S.D., n = 4.

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