Figure 3
Inhibition of P-gp and Bcrp by elacridar co-administration improves the brain distribution of ispinesib. The plasma concentrations (A), brain concentrations (B), and brain-to-plasma concentration ratios (C) of ispinesib at 2 and 6 hours post dose following a single intraperitoneal administration of 10 mg/kg ispinesib in FVB wild-type mice with or without 10 mg/kg elacridar co-dosing are illustrated. *p < 0.05 and **p < 0.01 for statistical comparison by unpaired t-test. Data represent mean ± S.D., n = 4.
