Figure 3
From: RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response
Treatment monitoring using the RISK6 signature in the Catalysis TB Treatment Cohort. (a) ROC curve depicting diagnostic performance of RISK6 for discriminating between active TB cases (irrespective of treatment outcome), sampled prior to treatment initiation (baseline, n = 87), and controls (n = 21) from the Catalysis Cohort. Shaded areas depict the 95% CI. The boxes in the top left corner represent the optimal (solid line) and minimum (dotted line) criteria set out in the target product profile for a screening/triage test for TB. (b) Comparison of RISK6 signature scores in cases (irrespective of treatment outcome) from the Catalysis Cohort at baseline and week 1 or week 4 after treatment initiation and after treatment completion (EoRx). Also shown are the RISK6 signature scores in healthy controls. Horizontal lines depict medians, the boxes the IQR and the whiskers the range. Violin plots depict the density of data points. The p-value, computed by Mann-Whitney U test, compares RISK6 signature scores after treatment completion with those in controls. (c) ROC curves depicting performance of RISK6 for discriminating between baseline (pre-treatment) samples and samples collected after week 1, week 4 or completion of TB treatment. (d) Prediction of treatment failure using RISK6. ROC curves depict discrimination between cases with cure (n = 70) and those with treatment failure (n = 7) in samples collected at treatment initiation (Baseline, red), at week 1 (blue), week 4 (green) and after treatment completion (EoRx, black). (e) RISK6 scores plotted versus total glycolytic activity index measured by PET-CT for all available samples.
