Table 1 Performance of RISK6 signature in the GC6 cohort by blinded validation, compared to the ACS 16-gene and RISK4 signatures.

From: RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

 

Gambia

South Africa

Ethiopia

AUC (95% CI)

p

AUC (95% CI)

p

AUC (95% CI)

p

RISK6

70% (59–81)

<0.0001

70% (61–79)

0.0015

66% (46–86)

0.028

ACS 16-gene

67% (56–78)

0.0016

72% (63–81)

<0.0001

60% (41–79)

0.11

RISK4*

72% (55–88)

0.0054

72% (53–92)

0.0063

67% (50–83)

0.02

  1. Samples from 0–24 months before TB diagnosis were included.
  2. *In the smaller GC6–74 test set only, because RISK4 was discovered in the GC6-74 training set (comprising Gambian and South African samples).
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