Figure 3
From: Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need
Sleep/wakefulness of the Sik1S577A mice after sleep deprivation. (a–c) Hourly time spent in wakefulness (a), NREMS (b), and REMS (c) of the Sik1+/+, Sik1S577A/+, and Sik1S577A/S577A mice after 6-h sleep deprivation. (d) NREMS delta power of the Sik1S577A mice under the basal state and for two hours after 6-h sleep deprivation. (e) NREMS delta density change of the Sik1S577A mice during ZT6-7, ZT8-9, and ZT10-11 h after 6-h sleep deprivation. (f) Hourly NREMS delta power density of the Sik1S577A mice after 6-h sleep deprivation. (g–i) EEG power spectra of the Sik1S577A mice during two hours after 6-h sleep deprivation during wakefulness (g), NREMS (h), and REMS (i). One-way repeated-measures analysis of variance (ANOVA) followed by Tukey’s test (a–c,f). Two-tailed paired T-test (d). Two-way ANOVA (e). One-way ANOVA followed by Tukey’s test (g–i). 13 male mice for each group. Data are presented as the mean ± SEM.
