Figure 6
From: miR-379 links glucocorticoid treatment with mitochondrial response in Duchenne muscular dystrophy
Glucocorticoid response of miR-379, EIF4G2 and DAPIT. (a) Foxo1, EIF4G2 and USMG5 mRNAs (normalized to p0 (RPLP0)), and miR-379-5p (normalized to U6/miR-93/miR-16), relative abundance in the gastrocnemius muscle of C57Bl/10 (n = 11), treated by dexamethasone (D), and untreated control (C). (b) and (c), Protein expression levels of Foxo1, EIF4G2 and DAPIT (normalized to total protein) in the gastrocnemius muscle of C57Bl/10 treated by dexamethasone (D) and untreated (C). (d) miR-139-5p and miR-379-5p expression in the plasma in a human cohort (each dot represents one patient, n = 9). Healthy control (Cont), DMD patients, untreated (DMD UT), and treated by glucocorticoid (DMD GC), of the age groups 4–8, 8–12 and 12–20 years old.
