Table 1 MiRNA expression in GRMD muscle biopsies.
From: miR-379 links glucocorticoid treatment with mitochondrial response in Duchenne muscular dystrophy
miR name | Chr. Hs | Fold-change (GRMD vs WT) | p-value (GRMD vs WT) | ||||||
---|---|---|---|---|---|---|---|---|---|
Severe GRMD | moderate GRMD | Severe GRMD | moderate GRMD | ||||||
Biceps f. | Sartorius c. | Biceps f. | Sartorius c. | Biceps f. | Sartorius c. | Biceps f. | Sartorius c. | ||
miR-30e-3p | 1 | −1.46 | −1.84 | −1.09 | −1.18 | * | |||
miR-30e-5p | 1 | −1.29 | −2.24 | 1.08 | 1.15 | ||||
miR-128–3p | 2 | 1.19 | −1.67 | 1.98 | 1.3 | ** | |||
miR-149-5p | 2 | 1.37 | 1.39 | 2.45 | 2.61 | *** | *** | ||
let-7g-5p | 3 | −1.02 | −1.25 | 2.01 | 2.02 | ** | ** | ||
miR-103a-3p | 5 | 1.36 | 1.9 | 1.63 | 2.48 | * | ** | **** | |
miR-378a-5p | 5 | 1.03 | −1.92 | 2.13 | 1.41 | ** | |||
miR-133b | 6 | −1.27 | −1.68 | 1.53 | 1.47 | * | * | ||
miR-206 | 6 | −1.02 | −1.42 | 1.58 | 1.55 | ||||
miR-106b-3p | 7 | 1.07 | −1.07 | 1.71 | 2.23 | ** | |||
miR-106b-5p | 7 | 1.13 | 1.12 | 1.93 | 1.84 | ** | * | ||
miR-320a | 8 | 1.06 | −1.18 | 1.32 | 1.34 | ||||
let-7d-5p | 9 | 1.54 | 1.46 | 2.01 | 2 | ** | ** | ||
miR-1307-3p | 10 | 1.42 | 1.44 | 1.96 | 2.54 | ** | ** | ||
miR-139-5p | 11 | 1.5 | −1.23 | 3.26 | 3.01 | *** | * | ||
miR-342-3p | 14 | 1.3 | 1.14 | 1.93 | 1.89 | ** | * | ||
miR-379-5p | 14 | 2.41 | 2.07 | 3.3 | 2.92 | ** | ** | *** | |
miR-410-3p | 14 | 5.05 | 5.3 | 8.37 | 7.21 | ** | ** | ** | *** |
miR-431-5p | 14 | 12.41 | 14.89 | 22.09 | 17.61 | *** | ** | ** | *** |
miR-433 | 14 | 4.87 | 4.77 | 7.43 | 6.39 | ** | * | *** | ** |
miR-487b-3p | 14 | 1.29 | 1.2 | 1.37 | 1.42 | ||||
miR-193b-3p | 16 | −1.2 | −1.61 | 1.9 | 1.72 | ** | |||
miR-484 | 16 | −1.41 | −1.3 | −1.14 | 1.65 | ||||
miR-142-3p | 17 | 3.1 | 4.15 | 3.09 | 5.12 | ** | * | ** | ** |
miR-21-5p | 17 | 4.83 | 10.18 | 2.63 | 8.28 | ** | ** | ** | **** |
miR-451a | 17 | −1.13 | 1.58 | 1 | 1.9 | * | |||
miR-133a | 18 | −1.28 | −1.91 | 1.69 | 1.51 | * | * | ||
miR-23a | 19 | 1.32 | 1.55 | 2.21 | 2.51 | ** | ** | ||
miR-199a-3p | 19 | 1.04 | 1.1 | −1.05 | 1.42 | ||||
miR-185-5p | 22 | −1.65 | −1.36 | −1.18 | 1.3 | ||||
miR-361-3p | X | 1.77 | 1.79 | 2.31 | 2.32 | * | ** | * | |
miR-361-5p | X | 1.23 | 1.02 | 2.25 | 2.13 | ** | ** | ||
miR-98-5p | X | −1.05 | −1.47 | 1.16 | 1.55 | ||||
miR-223-3p | X | 3.15 | 8.86 | 1.97 | 6.34 | * | * | ** |