Table 1 Analysis of Babesia microti antigenic proteins.

From: Antigen Discovery, Bioinformatics and Biological Characterization of Novel Immunodominant Babesia microti Antigens

GeneID*

Accession

Curated Domain Architecture

Function

Comments

BmR1_03g00785

XP_012648767.1

SIG + BAHCS1

adhesion/Cell surface/exported protein

 

BmR1_04g08155

XP_012650223.1

SIG + Bm-SERA1

adhesion/Cell surface/exported protein

 

BmR1_02g04285

XP_012648612.1

SIG + BmMCFRP1 /MN15/BMN1–15 Maltese cross form related protein

adhesion/Cell surface/exported protein

 

BmR1_03g04855

XP_012649578.1

SIG + PiβS1 ___domain

adhesion/Cell surface/exported protein

 

BmR1_03g00690

XP_012648749.1

SIG + EGF + EGF + EGF + EGF

adhesion/Cell surface/exported protein

 

BmR1_01g03455

XP_012647758.1

AP2 DNA-binding ___domain

Transcription

AP2

BmR1_02g00670

XP_012647909.2

TP + peptidylprolyl isomerase

Plastid protein folding protein

peptidylprolyl isomerase with a transit peptide

BmR1_03g03490

XP_012649309.1

sGTPase

Translation

elongation factor EF-1 alpha subunit

BmR1_04g06300

XP_012649865.1

SIG

adhesion/Cell surface/exported protein

 

BmR1_01g01121

XP_012647300.2

Apicomplexa specific ___domain (173–231)

Miscellaneous

Apicomplexan+Vitrella

BmR1_04g08775

XP_012650340.1

HSP90

Chaperone

HSP90

BmR1_02g02760

XP_012648315.1

NTN-HYDROLASE

protein degradation

20 S proteasomal Peptidase subunit

BmR1_03g00420

XP_012648695.1

Histone Fold

Chromatin

histone H2A

BmR1_01g01620

XP_012647389.1

PPR repeats

RNA binding and processing

 

BmR1_04g09905

XP_012650554.2

alpha-helical protein

Miscellaneous

Apicomplexan+Vitrella-specific

BmR1_02g02985

XP_012648359.1

BLBD (Biotin Lipid Binding ___domain)+E3_binding+dehydrogenase

Metabolism

 

BmR1_02g03700

XP_012648499.1

Acetyltransferase

Chromatin

Histone acetyltransferase 1

BmR1_04g07910

XP_012650176.1

ubiquitin+UBA

Ubiquitin

 

BmR1_02g03965

XP_012648551.1

RNA-Helicase

RNA binding and processing

RNA-Helicase

BmR1_03g00020

XP_012648615.2

SIG + PißS ___domain

adhesion/Cell surface/exported protein

 

BmR1_04g07535

XP_012650105.1

SIG + BmMCFRP /MN15/BMN1–15 Maltese cross form related protein

adhesion/Cell surface/exported protein

 

BmR1_02g00205

XP_012647816.1

SIG

adhesion/Cell surface/exported protein

 

BmR1_01g01845

XP_012647436.1

HAD phosphatase

Miscellaneous

Ortholog of Plasmodium HAD ___domain ookinete protein

BmR1_03g04120

XP_012649435.1

No Hit

Miscellaneous

 

BmR1_02g02345

XP_012648236.1

Pfimp2

Miscellaneous

Ortholog of Plasmodium Pfimp2 inner membrane proteins

BmR1_03g02795

XP_012649170.1

Babesia/Theileria specific ___domain

Miscellaneous

 

BmR1_03g02390

XP_012649089.1

Actin

Cytoskeleton

Actin

BmR1_04g05965

XP_012649799.1

Enolase_N + Enolase_C

Metabolism

Enolase

BmR1_02g01625

XP_012648094.1

GDI (Rossmann fold)

Signaling

Rab GDP dissociation inhibitor beta

BmR1_04g08040

XP_012650201.1

HSP70

Chaperone

Hsp70

BmR1_04g06288

XP_012649864.1

Nudix

Metabolism

Nucleotide NDP-X processing

BmR1_01g02215

XP_012647511.1

Pep3/Vps18/deep orange family

Golgi/Vacuolar sorting

 

BmR1_01g02270

XP_012647522.1

No Hit

Miscellaneous

 

BmR1_03g03070

XP_012649225.1

Ribosomal_L27A

Ribosomal Protein

large subunit ribosomal protein L27Ae

BmR1_03g02570

XP_012649124.1

SF-assemblin

Cytoskeleton

SF-assemblin/beta giardin

BmR1_03g04301

XP_012649471.1

UFD1

Ubiquitin

Ubiquitin fusion degradation protein UFD1

BmR1_02g00430

XP_012647861.1

Utp11

RNA binding and processing

UTP11 U3 small nucleolar RNA-associated protein 11

BmR1_03g02185

XP_012649047.1

BBOX

Ubiquitin

 

BmR1_03g03720

XP_012649355.1

Myosin-ATPase+BZIP + BetaPropeller

Cytoskeleton

 

BmR1_02g02765

XP_012648316.1

Zn-binding ___domain

Miscellaneous

 

BmR1_04g07165

XP_012650036.1

MIT + AAA + Vps4_C

Cytoskeleton

 

BmR1_01g03115

XP_012647688.1

cNMP_binding+cNMP_binding

Signaling

 

BmR1_03g02831

XP_012649178.2

Protein kinase

Signaling

 

BmR1_01g02860

XP_012647635.1

DDRP-beta

DNA replication/processing

DNA-directed RNA polymerase II subunit B

BmR1_03g02705

XP_012649152.1

N-OB + wHTH

DNA replication/processing

Replication A32

BmR1_03g02396

XP_012649091.1

IWS1

Chromatin

 

BmR1_03g01440

XP_012648898.1

RNA-Helicase

RNA binding and processing

inactive RNA helicase

BmR1_04g05525

XP_012649711.1

Peptidase_M24 + METPEPTIDASE-HTH

Miscellaneous

Metallopeptidase

BmR1_01g01485

XP_012647367.1

RNA-Helicase

RNA binding and processing

RNA-Helicase

BmR1_03g00861

XP_012648784.1

sGTPase

Signaling

 

BmR1_02g02755

XP_012648314.1

sGTPase

Signaling

 

BmR1_01g01670

XP_012647399.1

SIG + Thioredoxin+Thioredoxin_6+Thioredoxin

Surface/exported protein

ER lumen disulfide bond isomerase

BmR1_03g02230

XP_012649056.1

GOLD

Golgi/Vacuolar sorting

 

BmR1_04g09097

XP_012650403.1

Sec. 61_beta

secretion

 

BmR1_02g03525

XP_012648466.1

TM + TM + TM + TM + TM + TM + TM + TM + TM + TM + TM

Surface/exported protein

 

BmR1_04g09955

XP_012650565.1

Cpn60_TCP1

Chaperone

 
  1. *Genes are listed based on their high, medium and low immunogenic ranking shown in Fig. 2.