Figure 8
WT, but not p.P888L, SAP97 increases IK1 density. (a,b) Traces (a) and current density-voltage curves (b) of IK1 recorded in Sham, WT and p.P888L SAP97 cardiomyocytes. The inset in b represents data in an expanded scale. Each point represents the mean ± SEM of “n” experiments/cardiomyocytes from five mice of each group. *P < 0.05 vs Sham mice. (c) WB image and its corresponding stain-free gel showing Kir2.1 (arrow) expression in ventricular tissue from the three mouse groups. (d) Mean densitometric analysis of Kir2.1 levels normalized to the total protein.
