Table 1 Overview of the effects of post-natal penicillin V treatment in male and female mice compared to vehicle treated controls.
| Â | Males | Females | ||||
|---|---|---|---|---|---|---|
PenV | PenV+JB1 | PenV | PenV+JB1 | |||
Behaviour | Anxiety-like | — | — | — | — | |
Social interaction | ↓ | — | — | — | ||
Brain gene expression | AVPR 1a | HPC | ↓ | — | ↑ | — |
HPT | — | — | ↑ | — | ||
FC | — | — |  |  | ||
AVPR 1b | HPC | ↓ | — | ↑ | — | |
HPT | ↓ | — | — | — | ||
FC | ↓ | — | ↑ | — | ||
OxtR | HPC | — | — | — | — | |
HPT | — | — | — | — | ||
FC | — | — | — | — | ||
BDNF | HPC | ↓ | — | — | — | |
HPT | ↑ | — | — | — | ||
FC | — | — | — | — | ||
Claudin-5 | HPC | — | — | — | — | |
HPT | ↓ | — | — | — | ||
FC | ↓ | — | — | — | ||
Occludin | HPC | — | — | — | — | |
HPC | ↓ | — | — | — | ||
FC | ↓ | — | — | ↑ | ||
Immune parameters | Foxp3 + T cells | ↓ | — | — | — | |
IL-10 + Foxp3 + T cells | ↓ | — | — | ↑ | ||
CD80 + Dendritic cells | — | ↓ | — | ↓ | ||
CD86 + Dendritic cells | ↑ | — | — | — | ||
MHCII + Dendritic cells | ↑ | — | — | — | ||
Microbiome | α-Diversity | Week 3 | ↓ | ↓ | ↓ | ↓ |
|  | Week 6 | ↓ | ↓ | ↓ | ↓ | |
Proteobacteria | Week 3 | ↑ | ↑ | ↑ | ↑ | |
Week 6 | — | — | — | — | ||
Bacteroidetes | Week 3 | ↓ | — | ↓ | ↓ | |
Week 6 | — | — | — | — | ||
