Figure 7 | Scientific Reports

Figure 7

From: Tensile force-induced PDGF-BB/PDGFRβ signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement

Figure 7

The expressions of PDGFRβ-related pathway during OTM. (A) Protein expression of Runx-2, OCN, JAK2 and STAT3 was measured by immunohistochemistry (IHC) in tension area of Vehicle, Imatinib and AG490 groups at day 7 of OTM. (B) The semi-quantitative analysis for IHC. (C) Schematic graph illustrates the mechanism of the PDGF-BB/PDGFRβ/JAK-2/STAT3 signal axis regulating bone formation under tensile force during OTM. Each column represents the mean value of triplicate experiments. **p < 0.01 compared with the Vehicle group at day 7 of OTM, n = 8/group.

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