Table 6 Multivariate analysis with top associated targeted metabolites in the DIALONG study.

From: Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes

Metabolite

ba

p valuea

bb

p valueb

Glycine1

6.6

0.01

7.6

0.01

Serine1

− 0.1

0.95

0.6

0.73

Phenylalanine1

11.5

0.01

15.0

0.01

Thiamine monophosphate

− 4.7

0.01

− 5.5

0.01

  1. Correlation between Serine and Glycine is 0.46 in all (p = 0.0005), 0.51 in RPs (p = 0.007) and 0.3 in NPs (ns).
  2. Data were winsorized before analyses, statistical tests performed on log2-transformed data.
  3. NP non-progressors, RP rapid progressors. nNP = 25, nRP = 27.
  4. Linear regression models: Pa (adjusted for sex, age, FLI), Pb (adjusted for sex, age, FLI, HbA1c).
  5. 1Bevital GC–MS/MS, 2Bevital LC–MS/MS.
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