Figure 6
From: Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein
Schematics of a β-sheet enriched hTau40 oligomer templated by the anionic DMPG monolayer. (a) and (b) side views (in the plane of the membrane) shows an ordered tau oligomer associated with the anionic DMPG monolayer at the air/water interface (a). d-spacing and coherence lengths (Lxy) shown are for the hTau40 oligomer. Lc is the out-of-plane length of the coherently scattering moiety of the hTau40 assembly. A zoomed in schematic illustrates the cationic tau domains P1 and P2) (adopted from Wang et al.15) that might favorably interact with the anionic lipids (b). (c, d) top views (perpendicular to the membrane) of the membrane before (c) and after (d) hTau40 association. The Lxy values in these schematics are those of the ordered lipid domains for the {1,0} + {0,1} and {1,− 1} Bragg peaks. The orientation of the tau β-sheet arrangements vis-à -vis the orientation of the DMPG lattice cannot be determined from the experimental data. Schematics for K18 and hTau40/3Epi can be found in Figures S5 and S6 in Supplemental Information, respectively.
