Figure 1
From: Spray dried VSV-vectored vaccine is thermally stable and immunologically active in vivo
Measured log loss of VSVGFP activity after storage at 45 °C and < 10% RH for the positive (liquid) control, trehalose, trehalose/dextran 3:1, trehalose/dextran 1:3, mannitol/dextran 2:1, and dextran. Process loss attributed to spray drying is shown at t = 0 (spray dry production loss) and loss after 1 and 3 days of storage is compared. Data are represented as mean ± SEM from repeats for all formulations. The results of a two-way ANOVA between time points for each excipient formulation are shown where *P = 0.05, **P = 0.001, ***P = 0.0002, ****P < 0.0001, ns: not significant.
