Table 3 Changes in RV parameters, cardiac biomarkers and polysomnographic data before and after CPAP therapy.

From: Evaluation of right ventricular performance and impact of continuous positive airway pressure therapy in patients with obstructive sleep apnea living at high altitude

 

Before CPAP therapy

(n = 45)

After CPAP therapy

(n = 45)

P value

RAVI (ml/m2)

37.2 ± 4.9

32.9 ± 3.9

 < 0.001

RV apicobasal diameter (mm)

34.4 ± 3.4

35.3 ± 4.3

0.37

RV mediolateral diameter (mm)

30.8 ± 3.4

29.7 ± 2.9

0.14

RV long-axis diameter (mm)

67.9 ± 4.6

66.8 ± 3.9

0.28

RVWT (mm)

4.3 ± 0.5

4.2 ± 0.5

0.29

TAPSE (mm)

19.9 ± 2.1

19.8 ± 2.4

0.95

RV VTI (cm)

13.5 ± 2.4

13.9 ± 2.0

0.46

TV E/A

1.3 ± 0.2

1.2 ± 0.2

0.95

TV Sa (cm/s)

15.1 ± 2.7

14.5 ± 2.0

0.41

TV E/e’

5.4 ± 1.5

4.9 ± 1.0

0.54

Systolic PAP (mmHg)

44.6 ± 8.0

37.9 ± 6.9

0.001

High sPAP

22 (49%)

14 (31%)

0.001

PVR (Woods)

2.0 ± 0.4

1.7 ± 0.3

 < 0.001

RV GLS (− %)

20.3 ± 3.3

23.1 ± 3.1

0.001

RV LLS (− %)

20.7 ± 3.5

23.0 ± 3.0

0.006

RV SLS (− %)

18.3 ± 4.2

18.8 ± 4.1

0.63

RVEDV (ml)

101.7 ± 13.2

92.6 ± 11.9

0.005

RVESV (ml)

57.3 ± 10.4

47.0 ± 9.4

 < 0.001

RVEDVI (ml/m2)

55.5 ± 7.0

50.6 ± 7.0

0.007

RVESVI (ml/m2)

31.2 ± 5.6

25.7 ± 5.4

 < 0.001

RVEF (%)

43.9 ± 5.2

49.5 ± 4.9

 < 0.001

AHI (events/hour)

49.7 ± 16.4

4.9 ± 1.7

 < 0.001

Awake SaO2 (%)

93.0 ± 1.9

93.6 ± 1.8

0.27

Minimal SaO2 (%)

72.5 ± 8.4

84.3 ± 5.8

 < 0.001

Time SaO2 < 90% (min)

24.3 ± 12.0

3.4 ± 2.0

 < 0.001

CRP (mg/L)

5.7 ± 0.8

2.4 ± 1.1

 < 0.001

NT-proBNP (pg/ml)

554.5 ± 101.3

633.3 ± 115.4

0.24

cTnT (ng/ml)

 < 0.01

 < 0.01

1.00

  1. RAVI right atrial volume index, RV right wall, RVWT right ventricular wall thickness, TAPSE tricuspid annular plane systolic excursion, E/A ratio of early diastolic flow to atrial flow, Sa annular systolic velocity, E/Ea ratio of early diastolic flow to annular diastolic velocity, PAP pulmonary artery pressure, PVR pulmonary vascular resistance, GLS global longitudinal strain, LLS lateral longitudinal strain, SLS septal longitudinal strain, RVEDV right ventricular end-diastolic volume, RVESV right ventricular end-systolic volume, RVEDVI right ventricular end-diastolic volume index, RVESVI right ventricular end-systolic volume index, RVEF right ventricular ejection fraction, AHI apnea–hypopnea index, SaO2 saturation of arterial oxygen, CRP C-reactive protein, NT-proBNP N-terminal pro-B-type natriuretic peptide, cTnT cardiac troponin T.
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