Figure 3
From: UQCRH downregulation promotes Warburg effect in renal cell carcinoma cells
UQCRH overexpression partially overturns the Warburg effect in KMRC2. (a) UQCRH overexpression increased basal and ATP-linked oxygen consumption, detected by the Seahorse XF Mitochondrial Stress Test. (b) UQCRH overexpression increased glycolytic reserve, detected by the Seahorse XF Glycolytic Stress Test. (c) Unchanged intracellular ROS level in two KMRC2 sublines, detected by DCFDA assay. (d–e) Effect of UQCRH knockout in 786O on OCR in Mitochondrial Stress Test and ECAR in Glycolytic Stress Test. In all plots, data represent mean ± SD with n ≥ 4. ** P < 0.01, *** P < 0.001, ns P > 0.05, by unpaired t-test.
