Table 4 Risk factors between baseline PCT, CRP and NLR and death in patients with COVID-19 in the subgroup analysis.

From: Associations of procalcitonin, C-reaction protein and neutrophil-to-lymphocyte ratio with mortality in hospitalized COVID-19 patients in China

Laboratory tests

Characteristics

n

Model 0a

Model 1b

HR (95% CI)

P

HR (95% CI)

P

PCT, ng/mL (≥ 0.10 vs. < 0.1)

Age (< 60y)

37

3.76e+8 (0–Inf)

0.999

84,176.46 (0–Inf)

0.989

Age (≥ 60y)

39

10.08 (1.29–78.80)

0.028

53.76 (1.02–2,824.88)

0.049

Male

46

6.27 (0.79–49.89)

0.083

1.53e+6 (0–Inf)

0.989

Female

30

1.28e+9 (0–Inf)

0.999

1.58 (0–Inf)

0.999

Severe*

50

7.46 (0.98–56.54)

0.052

39.37 (1.50–1,036.84)

0.028

CRP, mg/L (≥ 52.14 vs. < 52.14)

Age (< 60y)

37

4.39 (0.48–39.73)

0.188

2.93e+13 (0–Inf)

0.990

Age (≥ 60y)

39

23.59 (3.01–185.03)

0.003

14.95 (0.78–287.68)

0.073

Male

46

6.37 (1.29–31.41)

0.023

2.29e+16 (0–Inf)

0.998

Female

30

3.06e+9 (0–Inf)

0.999

8.17e+20 (0–Inf)

0.948

Severe*

50

5.54 (1.26–24.28)

0.023

4.72 (0.91–24.56)

0.065

NLR (≥ 3.59 vs. < 3.59)

Age (< 60y)

37

3.38e+8 (0–Inf)

0.999

3.57e+8 (0–Inf)

0.998

Age (≥ 60y)

39

5.92 (0.74–47.58)

0.094

0 (0–Inf)

0.960

Male

46

3.56e+8 (0–Inf)

0.998

2.56e+8 (0–Inf)

0.999

Female

30

3.38 (0.4–28.28)

0.261

0 (0–Inf)

0.960

Severe*

50

0.81 (0.1–6.58)

0.841

3.47 (0.43–28.14)

0.244

  1. Data in bold indicate values of statistical significance.
  2. COVID-19 coronavirus disease 2019, HR hazard ratio, 95% CI confidence interval, PCT procalcitonin, CRP C-reaction protein, NLR neutrophil-to-lymphocyte ratio.
  3. aModel 0 was unadjusted.
  4. bModel 1 was adjusted for cancer, ARDS, hypohepatia, renal insufficiency, heart failure and shock.
  5. *Severe included critical severe and severe clinical types.
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