Figure 3
From: Lactobacillus reuteri DSM 17938 and ATCC PTA 5289 ameliorates chemotherapy-induced oral mucositis
Effects of L. reuteri (LR) mixture on 5-FU-induced inflammation. (A–D) Histopathological analysis (magnification x 400) of the oral mucosa of mice. (A) PBS i.p. with normal drinking water (PBS/water), (B) PBS i.p. and LR in drinking water (PBS/LR), (C) 5-FU i.p. with normal drinking water (5-FU/water), (D) 5-FU i.p. with LR in drinking water (5-FU/LR). Arrows indicate inflammatory cells. (E–H) Immunohistochemical analysis of the expression of pro-inflammatory mediators in the oral mucosa of mice. (E) nuclear NFκB p65, (F) IL-1β, (G) TNF-α, and (H) MPO. **p < 0.01; ***p < 0.001.
