Figure 4 | Scientific Reports

Figure 4

From: Photodynamic inactivation of Leishmania braziliensis doubly sensitized with uroporphyrin and diamino-phthalocyanine activates effector functions of macrophages in vitro

Figure 4

Two strategies for loading macrophages with doubly sensitized and photo-inactivated L. braziliensis. Lb, L. braziliensis transfected to express PBGD and ALAD; ALA, delta-aminolevulinate for 1st PS-sensitization by inducing cytosolic accumulation of URO; PC2, diamino-phthalocyanine for 2nd PS-sensitization via endosomal uptake; UV, Longwave UV (λmax = 366 nm) to excite URO in uroporphyric Lb; and RL, red light (λmax =  ~ 600 nm) to excite PC2 in the endosomes of Lb.

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