Figure 5 | Scientific Reports

Figure 5

From: Rejuvenation of mesenchymal stem cells by extracellular vesicles inhibits the elevation of reactive oxygen species

Figure 5

Proposed model: Infant extracellular vesicles rejuvenated elderly AT-MSCs by inhibiting the elevation of ROS. Elderly-derived AT-MSCs showed ROS accumulation due to the impairment of antioxidant enzymes, including SOD1 and SOD3, resulting in the suppression of the MEK/ERK pathway, which is involved in the function to decrease necrotic area. The incorporation of infant AT-MSC-derived EVs rejuvenated the elderly AT-MSCs by promoting the proliferation and expression of SOD1 and SOD3 and inhibiting the elevation of ROS levels and cellular senescence, thus resulting in improved functions of elderly AT-MSCs to decrease necrotic area.

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