Figure 7
From: A VCP modulator, KUS121, as a promising therapeutic agent for post-traumatic osteoarthritis
KUS121 suppresses the expression of IL-1β-induced cartilage-matrix proteases. Transcriptional levels of (a) MMP13, (b) MMP1, and (c) ADAMTS5 in chondrocytes cultured with IL-1β at 2 ng/mL or with 12.5, 25, 50, and 100 μM KUS121 for 12 h were determined using reverse-transcription quantitative polymerase chain reaction. RNA expression levels were normalised relative to the expression of GAPDH. Bars represent the median (n = 4), *P < 0.05, **P < 0.01 to IL-1β (second column) by Friedman test with Dunn’s post-test.
