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Figure 1

From: Non-basic amino acids in the hemagglutinin proteolytic cleavage site of a European H9N2 avian influenza virus modulate virulence in turkeys

Figure 1

Polymorphism in the hemagglutinin cleavage site (HACS) of European and non-European H9N2 sequences. The 3D structure of H9N2-K319 HA trimer showing P2 (residue 319) in blue, arginine in P1 (red) and glycine in P1´(green) was generated by SWISS-Model and further edited by Geneious (A). Alignment of the cleavage site of representative European viruses showing polymorphism (K, G, A, N, S, D) in position P2 (B). Prevalence of polymorphism in the HACS of European H9N2 (n = 82) (C) and Non-European H9N2 (n = 2926) (D) in H9N2-HA sequences retrieved from GISAID and GenBank on 20–01-2020. All sequences specifying S contains R in position P4. Positions P1 and P3 are highly conserved, while position P2 was more variable than P4, particularly in the European-H9N2 sequences (C-D). Structure and size of amino acids in position P2 are shown (E).

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