Table 2 Multivariable logistic regression analyses regarding the associations between intravenous heparin therapy and in-hospital outcomes.

From: Current practice and effects of intravenous anticoagulant therapy in hospitalized acute heart failure patients with sinus rhythm

Outcome

Model 1

Model 2

OR (95% CI)

p-value

OR (95% CI)

p-value

Primary

In-hospital death*

0.97 (0.91–1.03)

0.28

−

−

Secondary

Ischemic stroke†

1.49 (1.29–1.72)

 < 0.001

1.37 (1.18–1.59)

< 0.001

VTE‡

1.62 (1.14–2.30)

0.007

1.64 (1.14–2.34)

0.007

ICH§

1.18 (0.78–1.77)

0.43

1.07 (0.71–1.61)

0.75

Composite bleeding||

0.93 (0.79–1.09)

0.38

0.92 (0.78–1.08)

0.31

  1. CI: confidence interval, ICH: intracranial hemorrhage, OR: odds ratio, VTE: venous thromboembolism.
  2. *In-hospital death was adjusted for gender, age, admission route, New York Heart Association functional classification, history of hypertension, history of chronic kidney disease, history of life-threatening arrhythmia, shock, use of respirator, use of intravenous inotropes and use of intravenous vasopressor.
  3. † Model 1 was adjusted for history of hypertension, age, history of diabetes mellitus, history of stroke, vascular disease and gender. Model 2 was adjusted for model 1 with the confounders of in-hospital death.
  4. ‡ Model 1 was adjusted for history of hypertension, history of diabetes mellitus, history of hyperlipidemia and body mass index. Model 2 was adjusted for model 1 with the confounders of in-hospital death.
  5. § Model 1 was adjusted for history of hypertension, history of chronic kidney disease, history of liver disease, history of stroke, history of bleeding, age, use of anti-platelet agents or non-steroidal anti-inflammatory drugs and history of alcoholism. Model 2 was adjusted for model 1 with the confounders of in-hospital death.
  6. || Composite bleeding was defined as ICH and gastrointestinal bleeding during the indexed hospitalization. Model 1 was adjusted for history of hypertension, history of chronic kidney disease, history of liver disease, history of stroke, history of bleeding, age, use of anti-platelet agents or non-steroidal anti-inflammatory drugs and history of alcoholism. Model 2 was adjusted for model 1 with the confounders of in-hospital death.
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