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Figure 2

From: Angiotensin II type 1a receptor loss ameliorates chronic tubulointerstitial damage after renal ischemia reperfusion

Figure 2

Chronic tubulointerstitial damage at 70 days postischemia. (a,c,e) Immunohistochemical staining of type I collagen (a), type III collagen (c), and aquaporin-1 as a proximal tubular marker (e) in the IR kidneys. (b,d,f) Quantification of each positively stained area of type I collagen (b), type III collagen (d), and aquaporin-1 (f). Original magnification, × 100. (g,h) Gene expressions of α-1 collagen type I (g) and α-1 collagen type III (h). (i) Renal levels of hydroxyproline. The graphs show the fold-increase or -decease in each positively stained area or each gene expression in the IR kidney compared with the contralateral kidney (non-IR kidney). Values are means ± SE. *P < 0.05 vs. AT1a+/+ mice on the same day, #P < 0.05 vs. AT1a+/+  + Hyd mice on the same day.

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