Figure 3
From: Quantum chemical insight into the effects of the local electron environment on T2*-based MRI
T2* relaxation differentiates between Ga3+ and Fe3+. (A) 100 µM Ga(NO3)3 and Fe(NO3)3 solutions embedded in a 1% agarose gel in 4 mm O.D. quartz EPR tubes and scanned using a 7 T magnet to generate T2* maps. (B) Mean T2* relaxation times quantified using Slicer3D software by generating a 1 mm ROI for each phantom and calculating the mean T2* relaxation time using the data quantification package within the software. *p < 0.05 using a paired t-test. Error bars represent SEM of three replicates. (C) Representative T2* map of U251 glioblastoma cell pellets following a 3 h treatment of 120 µM Ga(NO3)3 or Fe(NO3)3. (D) Mean T2* relaxation times quantified using Slicer3D software by generating a 1 mm ROI for each phantom and calculating the mean T2* relaxation time using the data quantification package within the software. Error bars represent SD of n = 3 biological replicates. *p < 0.05 using a one-way ANOVA test.
