Table 2 Driver and nondriver mutations in aplastic anemia and myeloid neoplasms.

Interpretation	Patient/Age	Disease	VAF	Gene	Functional consequence	Amino acid change	Sample
Driver mutations	PR-17–25/72 y	Aplastic anemia	0.1105	ASXL1	Frameshift	p.P808fs	PBMCs
	PR-17–2/82 y	MDS-MLD	0.07735	U2AF1	SNV	p.S34F	WB
	PR-17–39/NA	MDS-MLD	0.49555	SRSF2	SNV	p.P95L	WB
			0.0864	CBL	SNV	p.L380P
			0.1591	GNAS	SNV	p.R201H
	PR-17–40/NA	MDS-MLD	0.3232	U2AF1	SNV	p.Q157R	WB
	PR-17–41/NA	AML-MRC	0.04445	ZRSR2	Stopgain	p.K106X	WB
	PR-18–77/70 y	MPN/MDS	0.0324	ASXL1	Frameshift	p.G642fs	WB
	PR-18–78/73 y	MDS-SLD	0.7453	EZH2	SNV	p.D659G	WB
	PR19-95/80 y	MDS-EB2	0.4073	SF3B1	SNV	p.K700E	WB
			0.40385	RUNX1	Stopgain	p.R201X
			0.3342	PTPN11	SNV	p.N58Y
	MDS-L2007	Cell line	0.67895	CEBPA	Stopgain	p.Q311X	Cell line
			0.6548	NRAS	SNV	p.G12A
			0.9569	TP53	Splicing	c.672+1G>A
Potential driver mutations	PR-18–77/70 y	MPN/MDS	0.74965	CUX1	Frameshift	p.R254fs	WB
Potential driver mutations	PR-18–78/73 y	MDS-SLD	0.0345	BCOR	Frameshift	p.E1182fs	WB
Nondriver mutations	PR-18–70/NA	MDS-EB1	0.04745	NOTCH1	SNV	p.L1531M	WB

MDS myelodysplastic syndrome, MDS-MLD MDS with multilineage dysplasia, AML-MRC acute myeloid leukemia with myelodysplasia-related changes, MPN, myeloproliferative neoplasm, MDS-SLD MDS with single lineage dysplasia, MDS-EB MDS with excess blasts, NA not available, PBMCs peripheral blood mononuclear cells, WB whole blood.

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