Table 2 Echocardiographic variables associated with disproportionate left atrial myopathy.
Echocardiographic variable | PROMIS-HFpEF cohort (n = 241) | β coefficient (SE) | P value |
|---|---|---|---|
Left heart structure/function | |||
LV end-diastolic volume index, mL/m2 | 41.1 (33.8–50.1) | − 0.55 (0.24) | 0.02 |
LV end-systolic volume index, mL/m2 | 16.5 (12.5–21.4) | − 0.24 (0.17) | 0.15 |
LV mass index, g/m2 | 102.5 (83.5–124.5) | 0.25 (0.22) | 0.27 |
Relative wall thickness | 0.45 (0.40–0.52) | 0.17 (0.34) | 0.62 |
LV ejection fraction, % | 60 (55–64) | 0.13 (0.43) | 0.77 |
LA volume index, mL/m2 | 38.4 (30.7–44.8) | 1.62 (0.17) | < 0.001 |
e' septal velocity, cm/s | 6.8 (5.3–8.3) | 0.09 (0.02) | 0.001 |
e' lateral velocity, cm/s | 9.7 (7.8–12.1) | 0.11 (0.02) | < 0.001 |
Average E/e' ratio | 12.2 (9.3–15.9) | − 0.03 (0.17) | 0.87 |
Early diastolic strain rate, 1/s | 1.10 (0.78–1.33) | 1.26 (0.15) | < 0.001 |
LV global longitudinal strain, % | 16.5 (13.3–18.5) | 1.4 × 10–4 (0.02) | 0.99 |
LA reservoir strain, % | 13.1 (9.2–22.2) | − 0.11 (0.004) | < 0.001 |
Right heart structure/function | |||
RV end-diastolic area, cm2 | 18.5 (15.0–22.3) | 0.02 (0.01) | 0.06 |
Right atrial area, cm2 | 19.5 (15.9–24.6) | 0.07 (0.01) | < 0.001 |
TAPSE, cm | 1.8 (1.6–2.1) | − 0.73 (0.17) | < 0.001 |
RV free wall strain, % | 21.6 (17.8–25.4) | − 0.04 (0.01) | 0.001 |
Hemodynamics | |||
PASP, mmHg | 42 (35–51) | 0.02 (0.005) | < 0.001 |
Pulmonary vascular resistance, WU | 2.2 (1.7–2.8) | 1.17 (0.19) | < 0.001 |
Stroke volume, mL | 72 (54–85) | − 1.05 (0.19) | < 0.001 |
Cardiac index, L/min/m2 | 2.40 (2.00–2.86) | − 0.36 (0.09) | < 0.001 |
CFR | 2.08 (1.78–2.50) | − 0.42 (0.13) | 0.002 |
