Table 4 Plasma proteins associated with disproportionate LA myopathy on multivariable linear regression in both PROMIS and Northwestern cohorts (validation).

From: Disproportionate left atrial myopathy in heart failure with preserved ejection fraction among participants of the PROMIS-HFpEF study

Protein

PROMIS-HFpEF (n = 241)

Northwestern HFpEF cohort (n = 117)

β-coefficient

SE

P value*

β-coefficient

SE

P value*

NT-proBNPa

0.12

0.04

0.005

0.25

0.07

0.0006

BNPa

0.11

0.04

0.007

0.20

0.06

0.003

PRELP

0.52

0.18

0.006

1.00

0.40

0.01

TRAP

− 0.29

0.13

0.03

− 0.37

0.18

0.04

VEGFD

0.24

0.07

0.002

0.52

0.20

0.009

DCN

0.25

0.12

0.04

0.56

0.25

0.03

  1. *False discovery rate-adjusted values. Adjusted for age, sex, and AF.
  2. aNT-proBNP and BNP were categorized as 1 distinct protein given BNP is a product of cleavage of NT-proBNP.
  3. BNP B-type natriuretic peptide, DCN decorin, NT-proBNP N-terminal pro-B-type natriuretic peptide, PRELP proline-arginine-rich end leucine-rich repeat protein, TRAP tartrate-resistant acid phosphatase, VEGFD vascular endothelial growth factor D.
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