Figure 1
From: Next generation of anti-PD-L1 Atezolizumab with enhanced anti-tumor efficacy in vivo
The Fc function removed the PD-L1 antibody, Maxatezo has the same binding affinity and inhibitory activity as Atezolizumab. (A) Binding affinities of Maxatezo and Atezolizumab, measured by Indirect ELISA against recombinant PD-L1. The square symbols represent Maxatezo, and the circular symbols represent Atezolizumab. The horizontal coordinate is antibody concentration and the vertical coordinate is absorbance value at 450Â nm. (B). Inhibitory affinity evaluation of Maxatezo and Atezolizumab, measured by in vitro cell-based Bioassay using the Jurkat-PD-1-NFAT cell line that stably expresses PD-1 with the reporter luciferase gene. The square symbol represents Maxatezo, and the circular symbol represents Atezolizumab. The horizontal coordinate is antibody concentration and the vertical coordinate is mean value of the relative fluorescence units (RLU).
