Figure 9
LLL12B and cisplatin combination suppressed tumor growth in D283 medulloblastoma xenografts. (A) Tumor volumes. (B) Tumor weights. (C) Body weight. (D) Western blots to analyze protein expression in the representative tumor samples. Expression levels of p-STAT3(Y705), STAT3, CyclinD1, Survivin, and GAPDH. D283 medulloblastoma cells (1 × 107 cells/tumor) were implanted subcutaneously into the flank region of 4 to 5 week-old female athymic nude mice. Mice were randomized into four groups (5 mice for each group) and treated with LLL12B (2.5 mg/kg, oral gavage, once daily) and/or cisplatin (5 mg/kg, intraperitoneal injection, once every 4 days) or vehicle alone.
