Figure 2 | Scientific Reports

Figure 2

From: Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

Figure 2

Blood glucose and plasma insulin levels during 90 min oral glucose tolerance test. (A) The fasting whole blood glucose levels were measured from tail blood samples after five hours of fasting in WT (n = 10), HET (n = 17) and HOM (n = 15) mice. (B) The fasting insulin concentrations were measured from retro-orbital blood samples in WT (n = 6), HET (n = 9) and HOM (n = 8) mice. (C) Whole blood glucose levels were measured from tail blood samples during OGTT in WT (n = 6), HET (n = 9) and HOM (n = 8). (D) Incremental AUC values (min*mmol/L) of whole blood glucose were calculated. (E) Plasma insulin concentrations were measured from retro-orbital blood samples during OGTT in the same mice. (F) Incremental AUC values (min*pmol/L) of plasma insulin levels were calculated. (G) Blood glucose levels were continuously recorded by telemetry during a 90 min OGTT in WT (n = 5), HET (n = 3) and HOM (n = 2) mice. (H) Activity levels, simultaneously recorded during OGTT, revealg high activity in HOM mice. (A, B, D, F) tested with one-way ANOVA with Dunnett’s multiple comparisons testing. ANOVA, analysis of variance; AUC, area under the curve; HET, heterozygous; HOM, homozygous; OGTT, oral glucose tolerance test; WT, wild-type.

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