Figure 2 | Scientific Reports

Figure 2

From: Daphnetin ameliorates acute lung injury in mice with severe acute pancreatitis by inhibiting the JAK2–STAT3 pathway

Figure 2

Daphnetin reduces lung damage and inflammation in mice with PALI. (A) Hematoxylin and eosin staining of the pancreas tissue, the magnification of each histological images were × 200. Arrows show alveolar thickening and inflammatory cell infiltration in lungs. (B) Scoring of alveolar septal capillary density in lung issues. Indicators of inflammation in lung tissue were detected by ELISA kits. The level of MPO (C) and TNF-α (D) and IL-6 (E) were reduced significantly after the pretreatment of daphnetin.The histograms were created using GraphPad 5 software(GraphPad Prism 5.01 http://www.xdowns.com/soft/xdowns2009.asp?softid=49668&downid=60&id=52443). CON group, l-arginine vehicle + daphnetin vehicle; SAP group, l-arginine + daphnetin vehicle; DAP group, l-arginine vehicle + daphnetin; SAP + DAP group, l-arginine + daphnetin. Data are presented as the mean ± SD. n = 6 /group. **P < 0.01 versus CON group. #P < 0.05 versus SAP group; ##P < 0.01 versus SAP group, n.s.P > 0.05 versus CON group. Scale bars: 50 μm.

Back to article page