Figure 3

Location of DNA fragments relative to nucleosomal dyads. (A) The density of fragment start and end sites with respect to nucleosome dyads for patients and controls. The vertical lines are drawn at 75 bp downstream and upstream of the nucleosome center to signify the region of nucleosome core and linker. (B) Copy number aberration quantification of all technical replicates containing fragments starting and ending within nucleosome core or linker regions. (C) The average relative copy number values from the 10 replicates of patient 2. The different colors indicate results from using fragments that start and end within nucleosome core region, and fragments that start and end within nucleosome linker region as well as all fragments with no selection.