Figure 2 | Scientific Reports

Figure 2

From: Dynamical modeling of miR-34a, miR-449a, and miR-16 reveals numerous DDR signaling pathways regulating senescence, autophagy, and apoptosis in HeLa cells

Figure 2

Synthetic gene regulatory network for the functional G1/S checkpoint. Arrows denote activations and hammer-head arcs represent inhibitions, respectively. Dashed hammer-head arcs represent targets of miRNA-34a, miR-449a and miR-16. The yellow rectangular nodes represent miRNAs and the red one denotes transfected miRNAs which induces DNA damage response in HeLa cells. The network outputs are in orange rectangular nodes represents proliferation or autophagy or apoptosis or senescence.

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