Figure 1

Schematic summary of the study design. ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; ARNI, angiotensin receptor-neprilysin inhibitor; BB, beta-blocker; HF, heart failure; HFrEF, heart failure with reduced ejection fraction; ICD-10, International Classification of Diseases 10th Revision; MRA, mineralocorticoid receptor antagonist; NYHA, New York Heart Association; SF-36, 36-Item Short Form Survey. *I50, I50.0, I50.1, I50.9, I11.0, I13.0, I13.2, I25.5, I42, I42.x.