Figure 6 | Scientific Reports

Figure 6

From: Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

Figure 6

Impact of AGF94 treatment on tumor infiltrating macrophages. To assess the impact on the immune populations in mice treated with AGF94, the immune populations from tumors and spleens were harvested after 2, 3, and 4 treatments. (A) Results are shown for the percentage of CD11b+ and F4/80+ macrophages. (B) Percentage of FRβ+, gated off CD11b+ and F4/80+ macrophages, are shown with 2, 3, or 4 doses of AGF94. (C) Percentage of Arg1+ FRβ+, gated off CD11b+ and F4/80+ macrophages, are shown following 2, 3 and 4 doses of AGF94. (D) Percentages of CD80+ FRβ+, gated off CD11b+ and F4/80+ macrophages, are shown following 2, 3, and 4 doses of AGF94. Results are shown for individual mice. Horizontal bars represent median values. Statistical comparisons were made between AGF94-treated and control groups. *p < 0.05.

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