Figure 1
From: Amplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma subgroup
Genomic findings regarding the tumors with 12q amplification. (A) Whole-genome copy number profiles generated from WGS for three NB tumors with 12q amplification and (B) copy number profiles for chromosome 12, 57–72 Mb from the p-terminal with corresponding amplification peaks. (C) Amplified regions at 12q14 in relation to genomic position and genes with the shortest region of overlap (SRO), indicated in blue, based on amplicon boundaries of all primary tumors and cell lines analyzed. (D) Amplified regions at 12q15 in relation to genomic position and genes with the SRO indicated in blue.
