Table 3 Correlation of RNF43 mutation with clinico-pathological parameters in colorectal carcinoma.

	Total		RNF43 mutant		RNF43 wildtype		p value
	n	%	n	%	n	%	p value
Total number of cases	220		13	5.9	207	94.1
Age
≤ 50 years	158	71.8	9	69.2	149	72.0	0.8321
> 50 years	62	28.2	4	30.8	58	28.0
Sex
Male	102	46.4	7	53.8	95	45.9	0.5777
Female	118	53.6	6	46.2	112	54.1
Tumour site
Left colon	167	75.9	6	46.2	161	77.8	0.0170*
Right colon	53	24.1	7	53.8	46	22.2
Histological type
Adenocarcinoma	190	86.4	10	76.9	180	87.0	0.3417
Mucinous carcinoma	30	13.6	3	23.1	27	13.0
pT
T1	7	3.3	0	0.0	7	3.5	0.7044
T2	22	10.5	1	8.3	21	10.6
T3	152	72.4	10	83.3	142	71.7
T4	29	13.8	1	8.3	28	14.1
pN
N0	104	49.8	7	58.3	97	49.2	0.5410
N1	63	30.1	2	16.7	61	31.0
N2	42	20.1	3	25.0	39	19.8
pM
M0	181	82.3	12	92.3	169	81.6	0.2839
M1	39	17.7	1	8.3	38	19.2
Tumour stage
I	26	11.9	1	7.7	25	12.1	0.6217
II	75	34.2	6	46.1	69	33.5
III	79	36.1	5	38.5	74	35.9
IV	39	17.8	1	7.7	38	18.5
Differentiation
Well differentiated	24	11.2	3	25.0	21	10.3	0.3775
Moderate differentiated	152	70.7	7	58.3	145	71.4
Poor differentiated	39	18.1	2	16.7	37	18.2
MMR-IHC
dMMR	73	33.2	10	76.9	63	30.4	0.0008*
pMMR	147	66.8	3	23.1	144	69.6
*BRAF* mutation
Present	8	3.6	1	7.7	7	3.4	0.4770
Absent	212	96.4	12	92.3	200	96.6
*APC* mutation
Present	128	58.2	3	23.1	125	60.4	0.0079*
Absent	92	41.8	10	76.9	82	39.6
*TP53* mutation
Present	112	50.9	3	23.1	109	52.7	0.0341*
Absent	108	49.1	10	76.9	98	47.3
*KRAS* mutation
Present	102	46.4	7	53.8	95	45.9	0.5777
Absent	118	53.6	6	46.2	112	54.1
*NRAS* mutation
Present	6	2.7	0	0.0	6	2.9	0.3892
Absent	214	97.3	13	100.0	201	97.1
Nuclear β catenin IHC
High	96	46.4	4	30.8	92	47.4	0.2365
Low	111	53.6	9	69.2	102	52.6

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