Figure 3 | Scientific Reports

Figure 3

From: Amelioration of injury-induced tissue acidosis by a nonsteroidal analgesic attenuates antinociceptive effects of the pH-dependent opioid agonist NFEPP

Figure 3

Antinociceptive efficacy of intraplantar (i.pl.) NFEPP after subcutaneous (s.c.) diclofenac. Dose- and time-dependent paw pressure threshold (PPT) elevations in inflamed paws after NFEPP (0.5–4 µg) injected i.pl. into inflamed paws, assessed after s.c. treatment with vehicle (A) or diclofenac (DCF; 20 mg/kg) (B) at 4 days after i.pl. complete Freund's adjuvant inoculation. All PPT elevations were statistically significant at + 5 min (P < 0.05 vs. 240 min, one-way RM ANOVA and Bonferroni test; not indicated for graph clarity). (C) DCF (20 mg/kg; s.c. daily for 4 days)-induced attenuation of PPT elevation produced by increasing doses of NFEPP (i.pl.) in inflamed paws at 5 min after NFEPP injection. P < 0.01 versus vehicle, area under the curve, two-tailed unpaired t-test. Data show means ± SEM (n = 8 rats per group).

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