Figure 4 | Scientific Reports

Figure 4

From: Amelioration of injury-induced tissue acidosis by a nonsteroidal analgesic attenuates antinociceptive effects of the pH-dependent opioid agonist NFEPP

Figure 4

Antinociceptive efficacy of intraplantar (i.pl.) fentanyl after subcutaneous (s.c.) diclofenac. Dose- and time-dependent paw pressure threshold (PPT) elevations in inflamed paws after fentanyl (0.5–4 µg) injected i.pl. into inflamed paws, assessed after daily s.c. treatment with vehicle (A) or diclofenac (DCF; 20 mg/kg) (B) at 4 days after i.pl. complete Freund's adjuvant inoculation. All PPT elevations were statistically significant (P < 0.05 vs. 240 min, one-way RM ANOVA and Bonferroni test; not indicated for graph clarity). (C) PPT elevations produced by increasing doses of fentanyl (i.pl.) in inflamed paws at 5 min after fentanyl injection were not different between vehicle- and DCF-pretreated groups. P > 0.05 versus vehicle, area under the curve, two-tailed unpaired t-test. Data show means ± SEM (n = 8 rats per group).

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