Figure 5
From: BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation
The depletion or inhibition of SMAD pathway attenuates lung cancer cell migration. (A) The cell migration abilities were reduced in SMAD1/5-depleted cells. Slides were observed under 10 × magnification. (B) Quantitative data derived from (B). Bar graphs represent the average number of migrated cells ± SD. At least three fields were counted for each condition. (C) Representative images of cell migration for each cell line. Cells were treated with 20 ng/ml rhBMP2 with or without BMP signaling inhibitor LDN193189 as indicated. Slides were observed under 10 × magnification. (D) Quantitative data derived from (C). Bar graphs represent the average number of migrated cell ± SD. At least three fields were counted for each condition. The p-value was determined by Student’s t test (*p < 0.05, **p < 0.01, ***p < 0.001).
