Figure 13 | Scientific Reports

Figure 13

From: The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1

Figure 13

CHD8 positively regulates transcription of its target promoters and the ASD gene module that co-expresses in human brain. (a) Expression of genes with CHD8 peak at the ± 5 Kb of the promoters showed a marked decrease compared to control. (b) Overlapping of ASD genes from SFARI-2020 list and genes with CHD8 binding at promoters46,47. Significance of the overlapping calculated with the hypergeometric test. (c) Gene expression of CHD8-bound ASD genes with significant change in RNA-seq experiment. (d) correlation analysis of CHD8-target ASD genes (same gene set we discovered in “c”) within the human fetal cortex (12–37 CPW) is plotted. The clusters of similarly expressed genes led to the separation of the same gene modules shown in “(c)”. A separate module of non-CHD8 target autism gene was randomly selected for correlation analysis of the control group.

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